Production and application of recombinant haemagglutinin neuraminidase of Newcastle disease virus

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Determination of immune potentials of recombinant fusion and recombinant haemagglutinin-neuraminidase antigens of Newcastle Disease virus (NDV)

Poultry sector is one of the major components of Indian animal husbandry and provides continuous and consistent income around the year to the poultry farmers. Further, animal products like meat and egg also bring foreign revenue into the country. The growing demand for acceptance in the global market for poultry products warrants ISSN: 2319-7706 Volume 4 Number 1 (2015) pp. 575-588 http://www.i...

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Molecular characterization of haemagglutinin-neuraminidase gene among virulent Newcastle disease viruses isolated in Iran

Background: Virulent Newcastle disease virus (vNDV) causes great economic losses to the poultry industry throughout the world. Despite the endemicity of Newcastle disease (ND) and occurrence of recurrent outbreaks, the nature and genetic features of circulating NDV strains in Iran are largely unknown. Aims: This study was conducted to characterize 13 NDV isolat...

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Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus.

The nucleotide sequence of the haemagglutinin-neuraminidase (HN) gene of Newcastle disease virus (NDV) has been determined. The HN gene is 2031 nucleotides long, approximately 13.5% of the viral genome. The nucleotide sequence contains a single long open reading frame which would encode a protein of 577 amino acids, with a mol. wt. of 63,149. This is in good agreement with estimates of the mole...

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Newcastle disease virus fusion and haemagglutinin-neuraminidase proteins contribute to its macrophage host range

The fusion (F) and haemagglutinin-neuraminidase (HN) proteins of Newcastle disease virus (NDV) are multifunctional proteins that play critical roles during infection. Here, we assessed the ability of NDV to replicate in macrophages and investigated the contribution of the F and HN proteins to NDV infection/replication in these cells. Results of our study revealed that, while presenting similar ...

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Tumorcidal Effect of Recombinant Newcastle Disease Virus

We have generated GFP expressing recombinant Newcastle Disease Virus (rNDV-GFP) based on a live vaccine strain which contains a less pathogenic cleavage site of F protein leading to restricted viral growth in vivo. We evaluated the rNDV have an effect of oncolytic activity to B16 melanoma cell. The rNDV-GFP infected efficiency to B16 cells and induced cell death. Apoptosis-related genes, Bax an...

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ژورنال

عنوان ژورنال: Asian Pacific Journal of Tropical Medicine

سال: 2010

ISSN: 1995-7645

DOI: 10.1016/s1995-7645(10)60152-6